Abbreviations used within SpotRM

ADR

adverse drug reaction

AE

adverse event

COX

cyclooxygenase

CYP

cytochrome P450

DILI

drug induced liver injury

DRESS

drug reaction with eosinophilia and systemic symptoms

EMA

European Medicines Agency

FDA

Food and Drug Administration (USA)

GSH

glutathione

GST

glutathione transferase

HLM

human liver microsomes

HRP

horseradish peroxidase

HSA

human serum albumin

IADR

idiosyncratic adverse drug reaction

MAO

monoamine oxidase

MBI

mechanism-based inhibition

MIST

metabolites in safety testing inhibition

MPO

myeloperoxidase

NSAID

nonsteroidal anti-inflammatory drug

RM

reactive metabolite

SULT

sulfotransferase

TDI

time-dependent inhibition

UGT

UDP-glucuronosyltransferase

ULN

upper level of normal